In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers
are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Abstract Background Extracellular vesicles (EVs) harbor thousands of proteins that hold
promise for biomarker development. Usually difficult to purify, EVs in urine are relatively …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …

Finding useful biomarkers for Parkinson’s disease | Science Translational Medicine news
careers commentary Journals Science Science brought to you byGoogle Indexer Log in science …

The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane
receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the …

Parkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical
motor features associated. Pathologically, it is characterized by the intracellular …

Proteins can provide insights into biological processes at the functional level, so they are
very promising biomarker candidates. The quantification of proteins in biological samples …

Alzheimer's disease (AD) is the most common cause of dementia, characterized by
progressive cognitive decline. The main disease hallmarks include amyloid beta aggregates …