Virus infection induces different cellular responses in infected cells. These include cellular
stress responses like autophagy and unfolded protein response (UPR). Both autophagy and …

The unfolded protein response (UPR) is a stress response activated by the accumulation of
unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) and its …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Breast cancer, which is the most common malignant tumor among women worldwide and an
important cause of death in women. The existing prognostic model for patients with breast …

The development of biological technologies in genomics, proteomics, and bioinformatics
has led to the identification and characterization of the complete set of coding genes and …

PERK is one of the transmembrane sensors of unfolded protein response (UPR) triggered
by ER stress. In this study, we evaluated the role of PERK in the sensitivity of hepatocellular …

Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed,
by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing …

The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global
surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents …

Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of
actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable …