Mass spectrometry (MS) instruments and experimental protocols are rapidly advancing, but
the software tools to analyse tandem mass spectra are lagging behind. We present a …

Over the past decade peptide sequencing by collision induced dissociation (CID) has
become the method of choice in mass spectrometry-based proteomics. The development of …

Protein post‐translational modifications (PTMs) represent important regulatory states that
when combined have been hypothesized to act as molecular codes and to generate a …

Advances in phosphopeptide enrichment methods enable the identification of thousands of
phosphopeptides from complex samples. Current offline enrichment approaches using TiO …

How non-coding DNA gives rise to new protein-coding genes (de novo genes) is not well
understood. Recent work has revealed the origins and functions of a few de novo genes, but …

The complexity of peptide mixtures that are analyzed in proteomics necessitates
fractionation by multidimensional separation approaches prior to mass spectrometric …

One of the limiting factors in determining the sensitivity of tandem mass spectrometry using
hybrid quadrupole orthogonal acceleration time-of-flight instruments is the duty cycle of the …

Protein phosphorylation is instrumental to early signaling events. Studying system-wide
phosphorylation in relation to processes under investigation requires a quantitative …

Circadian rhythms are self-sustained and adjustable cycles, typically entrained with
light/dark and/or temperature cycles. These rhythms are present in animals, plants, fungi …

Salmonella enterica serovar Typhimurium is a primary cause of enteric diseases and has
acquired a variety of virulence factors during its evolution into a pathogen. Secreted …