Curcumin analogues and derivatives with anti-proliferative and anti-inflammatory activity: Structural characteristics and molecular targets
E Chainoglou, D Hadjipavlou-Litina - Expert opinion on drug …, 2019 - Taylor & Francis
ABSTRACT Introduction: Curcumin (Diferuloylmethane) is a natural phenolic compound,
which belongs to the curcuminoid family, presenting pleiotropic activity and low …
which belongs to the curcuminoid family, presenting pleiotropic activity and low …
Bioactivities of EF24, a novel curcumin analog: a review
Y He, W Li, G Hu, H Sun, Q Kong - Frontiers in Oncology, 2018 - frontiersin.org
Curcumin is an attractive agent due to its multiple bioactivities. However, the low oral
bioavailability and efficacy profile hinders its clinical application. To improve the …
bioavailability and efficacy profile hinders its clinical application. To improve the …
Piperlongumine analogue L50377 induces pyroptosis via ROS mediated NF-κB suppression in non-small-cell lung cancer
Q Li, L Chen, Z Dong, Y Zhao, H Deng, J Wu… - Chemico-Biological …, 2019 - Elsevier
Natural products with potent activity and less toxicity provide major sources for development
of novel anti-cancer drugs. Herein, we evaluated the effects and the underlying mechanisms …
of novel anti-cancer drugs. Herein, we evaluated the effects and the underlying mechanisms …
Design, synthesis, and evaluation of chalcone analogues incorporate α, β-Unsaturated ketone functionality as anti-lung cancer agents via evoking ROS to induce …
M Zhu, J Wang, J Xie, L Chen, X Wei, X Jiang… - European Journal of …, 2018 - Elsevier
Chalcone, a natural structure, demonstrates many pharmacological activities including
anticancer, and one promising mechanism is to modulate the generation of ROS. It has been …
anticancer, and one promising mechanism is to modulate the generation of ROS. It has been …
Anticarcinogenic potency of EF24: an overview of its pharmacokinetics, efficacy, mechanism of action, and nanoformulation for drug delivery
I Sazdova, M Keremidarska-Markova, D Dimitrova… - Cancers, 2023 - mdpi.com
Simple Summary This study summarizes the current state of knowledge about the anticancer
potential of the curcumin analog EF24, including its pharmacokinetic profile, therapeutic …
potential of the curcumin analog EF24, including its pharmacokinetic profile, therapeutic …
Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo
WH Zhang, S Chen, XL Liu, XW Liu, Y Zhou - Bioorganic & Medicinal …, 2020 - Elsevier
The our previous study synthesized the chrysin-chromene-spirooxindole hybrids 3, and
further found compound 3e had good antitumor activity against A549 cells in vitro through …
further found compound 3e had good antitumor activity against A549 cells in vitro through …
Cocrystallization of 5-fluorouracil and l-phenylalanine: the first zwitterionic cocrystal of 5-fluorouracil with amino acid exhibiting perfect in vitro/vivo pharmaceutical …
LL Wang, LY Wang, YM Yu, YT Li, ZY Wu, CW Yan - CrystEngComm, 2020 - pubs.rsc.org
In order to highlight the advantages of L-phenylalanine (Phe) in the optimization of the in
vitro/vivo properties of the anticancer drug 5-fluorouracil (Fu) along with the enhancement in …
vitro/vivo properties of the anticancer drug 5-fluorouracil (Fu) along with the enhancement in …
Anti-inflammatory activity of ortho-trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives in vitro and in vivo
Z Wang, W Mu, P Li, G Liu, J Yang - European Journal of Pharmaceutical …, 2021 - Elsevier
Curcumin was reported as an anti-inflammatory agent. However, curcumin's poor
bioavailability limited its clinical utility. Here, thirty ortho-substituted mono-carbonyl curcumin …
bioavailability limited its clinical utility. Here, thirty ortho-substituted mono-carbonyl curcumin …
[HTML][HTML] Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl …
G Hao, J Zhai, H Jiang, Y Zhang, M Wu, Y Qiu… - Biomedicine & …, 2020 - Elsevier
Acetylshikonin, a natural naphthoquinone derivative compound from Lithospermum
erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor …
erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor …
Rational design, synthesis, and pharmacological characterisation of dicarbonyl curcuminoid analogues with improved stability against lung cancer via ROS and ER …
T Wei, Z Zheng, X Wei, Y Liu, W Li, B Fang… - Journal of Enzyme …, 2022 - Taylor & Francis
Curcumin is a natural medicine with a wide range of anti-tumour activities. However, due to
β-diketone moiety, curcumin exhibits poor stability and pharmacokinetics which significantly …
β-diketone moiety, curcumin exhibits poor stability and pharmacokinetics which significantly …