Cellular senescence is a complex cell state that can occur during physiological ageing or
after exposure to stress signals, regardless of age. It is a dynamic process that continuously …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

Cognitive deficits are a common comorbidity with neurological disorders and normal aging.
Inflammation is associated with multiple diseases including classical neurodegenerative …

The contemporary understanding that the immune response significantly supports higher
brain functions has emphasized the notion that the brain's condition is linked in a complex …

The etiopathogenesis of late-onset Alzheimer's disease (AD) is increasingly recognized as
the result of the combination of the aging process, toxic proteins, brain dysmetabolism, and …

Background Perivascular space (PVS) enlargement in ageing and Alzheimer's disease (AD)
and the drivers of such a structural change in humans require longitudinal investigation …

Normal aging often results in an increase in physiological tremors and slowing of the
movement of the hands, which can impair daily activities and quality of life. This study, using …

Aging is associated with reduction in the severity of alcohol misuse. However, the
psychological and neural mechanisms underlying the age‐related changes remain unclear …

Precisely assessing an individual's immune age is critical for developing targeted aging
interventions. Although traditional methods for evaluating biological age, such as the use of …

Yakutia is one of the coldest permanently inhabited regions in the world, characterized by a
subarctic climate with average January temperatures near− 40° C and the minimum below …