The role of the macrophage is an area of emerging interest in tendinopathy and tendon
healing. The macrophage has been found to play a key role in regulating the healing …

Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system
(MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by …

Tendon disorders represent a very common pathology in today's population, and
tendinopathies that account 30% of tendon-related injuries, affect yearly millions of people …

Although inflammation is necessary during the early phases of tissue repair, persistent
inflammation contributes to fibrosis. Acute tendon injuries often heal through a fibrotic …

Tendon is a highly organized tissue that transmits forces between muscle and bone. The
architecture of the extracellular matrix of tendon, predominantly from collagen type I, is …

Tendons perform a critical function in the musculoskeletal system by integrating muscle with
skeleton and enabling force transmission. Damage or degeneration of these tissues leads to …

Purpose: Tendon overuse injuries are prevalent conditions with limited therapeutic options
to halt disease progression. The specialized extracellular matrix (ECM) both enables joint …

During tendon healing, macrophages are thought to be a key mediator of scar tissue
formation, which prevents successful functional restoration of the tendon. However …

The wide variety of cell and tissue culture systems used to study and engineer tendons can
make it difficult to choose the best approach and “optimal” culture conditions to test a given …