Nipah virus disease: epidemiological, clinical, diagnostic and legislative aspects of this unpredictable emerging zoonosis

L Bruno, MA Nappo, L Ferrari, R Di Lecce, C Guarnieri… - Animals, 2022 - mdpi.com
Simple Summary This review summarizes fundamental aspects of Nipah virus (NiV)
infection with particular emphasis on disease in swine and its zoonotic potential, focusing on …

The immunobiology of Nipah virus

YJM Liew, PAS Ibrahim, HM Ong, CN Chong, CT Tan… - Microorganisms, 2022 - mdpi.com
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that emerged in Malaysia in
1998. It is a human pathogen capable of causing severe respiratory infection and …

[HTML][HTML] Learning from prepandemic data to forecast viral escape

NN Thadani, S Gurev, P Notin, N Youssef, NJ Rollins… - Nature, 2023 - nature.com
Effective pandemic preparedness relies on anticipating viral mutations that are able to
evade host immune responses to facilitate vaccine and therapeutic design. However, current …

Structure and design of Langya virus glycoprotein antigens

Z Wang, M McCallum, L Yan… - Proceedings of the …, 2024 - National Acad Sciences
Langya virus (LayV) is a recently discovered henipavirus (HNV), isolated from febrile
patients in China. HNV entry into host cells is mediated by the attachment (G) and fusion (F) …

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

TC Marcink, G Zipursky, W Cheng, K Stearns… - Science …, 2023 - science.org
Paramyxoviruses—including important pathogens like parainfluenza, measles, and Nipah
viruses—use a receptor binding protein [hemagglutinin-neuraminidase (HN) for …

Therapeutic administration of a cross-reactive mAb targeting the fusion glycoprotein of Nipah virus protects nonhuman primates

L Zeitlin, RW Cross, C Woolsey, BR West… - Science Translational …, 2024 - science.org
No licensed vaccines or therapies exist for patients infected with Nipah virus (NiV), although
an experimental human monoclonal antibody (mAb) cross-reactive to the NiV and Hendra …

Recombinant vesicular stomatitis virus–vectored vaccine induces long-lasting immunity against Nipah virus disease

C Woolsey, V Borisevich, AC Fears… - The Journal of …, 2023 - Am Soc Clin Investig
The emergence of the novel henipavirus, Langya virus, received global attention after the
virus sickened over three dozen people in China. There is heightened concern that …

Potent monoclonal antibody–mediated neutralization of a divergent Hendra virus variant

Z Wang, HV Dang, M Amaya, Y Xu… - Proceedings of the …, 2022 - National Acad Sciences
Hendra virus (HeV) and Nipah virus (NiV) are deadly zoonotic Henipaviruses (HNVs)
responsible for recurrent outbreaks in humans and domestic species of highly fatal (50 to …

[HTML][HTML] Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

J Lederhofer, Y Tsybovsky, L Nguyen, JE Raab… - Immunity, 2024 - cell.com
Continuously evolving influenza viruses cause seasonal epidemics and pose global
pandemic threats. Although viral neuraminidase (NA) is an effective drug and vaccine target …

Structure and supramolecular organization of the canine distemper virus attachment glycoprotein

D Kalbermatter, JM Jeckelmann… - Proceedings of the …, 2023 - National Acad Sciences
Canine distemper virus (CDV) is an enveloped RNA morbillivirus that triggers respiratory,
enteric, and high incidence of severe neurological disorders. CDV induces devastating …