Therapeutic potential of foldamers: from chemical biology tools to drug candidates?
Over the past decade, foldamers have progressively emerged as useful architectures to
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
mimic secondary structures of proteins. Peptidic foldamers, consisting of various amino acid …
Peptide science: A “rule model” for new generations of peptidomimetics
Peptides have been heavily investigated for their biocompatible and bioactive properties.
Though a wide array of functionalities can be introduced by varying the amino acid …
Though a wide array of functionalities can be introduced by varying the amino acid …
Exploring a β-Amino Acid with a Seven-Membered Ring Constraint as a Foldamer Building Block for Nontraditional Helices
We explored trans-and cis-2-aminocycloheptanecarboxylic acid (ACHpC) as potential
building blocks for helical foldamers. trans-ACHpC does not show sufficient folding …
building blocks for helical foldamers. trans-ACHpC does not show sufficient folding …
C11/C9 Helical Folding in αβ Hybrid Peptides Containing 1‐Amino‐cyclohexane acetic acid (β3, 3‐Ac6c)
The present study describes the solid‐state conformation of αβ hybrid peptides, Boc‐Leu‐
β3, 3‐Ac6c‐OH, P1; Boc‐Leu‐β3, 3‐Ac6c‐Leu‐β3, 3‐Ac6c‐OMe, P2; and Boc‐Leu‐β3, 3 …
β3, 3‐Ac6c‐OH, P1; Boc‐Leu‐β3, 3‐Ac6c‐Leu‐β3, 3‐Ac6c‐OMe, P2; and Boc‐Leu‐β3, 3 …
Side chain-specific 11/9-helix propensity of α/β-peptides with alternating residue types
J Lee, J Shim, P Kang, MG Choi… - Organic & Biomolecular …, 2018 - pubs.rsc.org
The 11/9-helix is among the most stable and non-traditional helical structures for α/β-
peptides with alternating residue types. The effect of side chain groups of α-residues and β3 …
peptides with alternating residue types. The effect of side chain groups of α-residues and β3 …
Promotion of 11/9‐helical folding in α/β‐peptides containing β2‐homoalanine residue
Abstract The 11/9‐helix is one of nontraditional helices available to α/β‐peptides with
alternating residue types. Several β‐amino acid residues are known to promote 11/9‐helical …
alternating residue types. Several β‐amino acid residues are known to promote 11/9‐helical …
Cooperative Effect of the Two Hydrogen Bonding Types on 11/9‐Helical Folding of α/β‐Peptides
α/β‐Peptide 11/9‐helix is an unconventional helical structure in which 11‐and 9‐membered
ring hydrogen bonds alternate along the helical axis. We have examined the interplay and …
ring hydrogen bonds alternate along the helical axis. We have examined the interplay and …
Conformation of Achiral α/β Hybrid Peptides Containing Glycine and 1‐Aminocyclohexaneacetic Acid
The present work describes the conformation of achiral α/β hybrid peptides, Boc‐Gly‐β3, 3‐
Ac6c‐NHMe (P1), Boc‐Gly‐β3, 3‐Ac6c‐Gly‐OMe (P2), and Boc‐Gly‐β3, 3‐Ac6c‐Gly‐β3, 3 …
Ac6c‐NHMe (P1), Boc‐Gly‐β3, 3‐Ac6c‐Gly‐OMe (P2), and Boc‐Gly‐β3, 3‐Ac6c‐Gly‐β3, 3 …
[图书][B] Modulating the Binding Energy of Synthetic Peptide Ligands Towards Bio-Molecular Targets
HR Reese - 2019 - search.proquest.com
Peptides form an immense class of functional biomolecules currently employed in a myriad
of applications encompassing the medicinal, biomedical, biomanufacturing, and material …
of applications encompassing the medicinal, biomedical, biomanufacturing, and material …