The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

Myocardial passive stiffness is crucial for the heart's pump function and is determined by
mechanical elements, including the extracellular matrix and cytoskeletal filaments; however …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

Muscle contraction is produced via the interaction of myofilaments and is regulated so that
muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and …

BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …

During natural aging, skeletal muscle experiences impairments in mechanical performance
due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross …

Hibernation is a period of metabolic suppression utilized by many small and large mammal
species to survive during winter periods. As the underlying cellular and molecular …

Contraction in striated muscle is classically described as regulated by calcium-mediated
structural changes in the actin-containing thin filaments, which release the binding sites for …

Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …