Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform
describing the phenotypic interaction between drugs, biological networks, and disease …

Digestive inflammation is a widespread global issue that significantly impacts quality of life.
Recent advances have highlighted the unique potential of therapeutic peptides for treating …

Quercetin was extracted from Portulaca oleracea L. through biphasic acid hydrolysis to
investigate its potential as a suppressor of dipeptidyl peptidase IV (DPP‐IV) and its …

In the current study, we established a comprehensive quantitative systems pharmacology
(QSP) model using linagliptin as the model drug, where drug disposition, drug intervention …

Background: Glucagon-like peptide 1 (GLP-1) is a hormone that promotes insulin secretion,
delays gastric emptying, and inhibits glucagon secretion. The GLP-1 receptor agonists have …

Alogliptin is a highly selective inhibitor of dipeptidyl peptidase-4 and primarily excreted as
unchanged drug in the urine, and differences in clinical outcomes in renal impairment …

Target-mediated drug disposition (TMDD) represents a pivotal phenomenon in
pharmacology, where the interaction between a potent drug and its pharmacological target …

Diagnostic features for metabolic syndrome include cardiovascular risk factors, like
increased abdominal circumference, triglycerides, and blood pressure, and are mainly …