Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-
terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD …

The gasdermins are a family of pore-forming proteins that have recently emerged as
executors of pyroptosis, a lytic form of cell death that is induced by the innate immune …

Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis
downstream of inflammasome activation and was previously shown to form large …

Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-
mediated cleavage before inducing pyroptosis. We here discovered a form of pyroptosis …

Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors.
The pathological changes associated with IVDD include the excessive accumulation of …

Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in
intensive care units. No specific therapy is available at present for this cardiac dysfunction …

Mitochondria have multiple functions such as supplying energy, regulating the redox status,
and producing proteins encoded by an independent genome. They are closely related to the …

Diverse inflammatory conditions, from infections to autoimmune disease, are often
associated with cellular damage and death. Apoptotic cell death has evolved to minimize its …

Mitochondria are cellular factories for energy production, calcium homeostasis and iron
metabolism, but they also have an unequivocal and central role in intrinsic apoptosis …