[HTML][HTML] Distinct landscape and clinical implications of therapy-related clonal hematopoiesis
Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in
individuals previously treated with chemotherapy and/or radiation therapy. With the …
individuals previously treated with chemotherapy and/or radiation therapy. With the …
[HTML][HTML] CHIP: a clonal odyssey of the bone marrow niche
WE Schleicher, B Hoag, M De Dominici… - The Journal of Clinical …, 2024 - jci.org
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …
Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescuing and cancer mutations
Telomere biology disorders (TBD), caused by pathogenic germline variants in telomere-
related genes, present with multi-organ disease and a predisposition to cancer. Clonal …
related genes, present with multi-organ disease and a predisposition to cancer. Clonal …
PPM1G promotes autophagy and progression of pancreatic cancer via upregulating HMGB1
M Song, M Xu, Q Zhang, T Fan, J Xu, C Hang… - Cellular …, 2024 - Elsevier
Pancreatic cancer remains one of the most aggressive and lethal malignancies worldwide,
with a dismal 5-year relative survival rates of only 12%. Therefore, it is urgent to discover the …
with a dismal 5-year relative survival rates of only 12%. Therefore, it is urgent to discover the …
[HTML][HTML] PPM1D activity promotes cellular transformation by preventing senescence and cell death
M Stoyanov, AS Martinikova, K Matejkova… - Oncogene, 2024 - nature.com
Cell cycle checkpoints, oncogene-induced senescence and programmed cell death
represent intrinsic barriers to tumorigenesis. Protein phosphatase magnesium-dependent 1 …
represent intrinsic barriers to tumorigenesis. Protein phosphatase magnesium-dependent 1 …
[HTML][HTML] Clonal hematopoiesis in children with predisposing conditions
Clonal hematopoiesis in children and young adults differs from that occuring in the older
adult population. A variety of stressors drive this phenomenon, sometimes independent of …
adult population. A variety of stressors drive this phenomenon, sometimes independent of …
[HTML][HTML] The role of clonal progression leading to the development of therapy-related myeloid neoplasms
L Guarnera, MR Pascale, H Hajrullaj, A Cristiano… - Annals of …, 2024 - Springer
Therapy-related myeloid neoplasms (t-MN) are characterized by aggressive features and a
dismal prognosis. Recent evidence suggests a higher incidence of t-MN in individuals …
dismal prognosis. Recent evidence suggests a higher incidence of t-MN in individuals …
[HTML][HTML] Therapy-Related Myeloid Neoplasms: Complex Interactions among Cytotoxic Therapies, Genetic Factors, and Aberrant Microenvironment
Therapy-related myeloid neoplasm (t-MN), characterized by its association with prior
exposure to cytotoxic therapy, remains poorly understood and is a major impediment to long …
exposure to cytotoxic therapy, remains poorly understood and is a major impediment to long …
Association of PARP inhibitor treatment on the prevalence and progression of clonal hematopoiesis in patients with advanced prostate cancer
Background Poly ADP‐ribose polymerase (PARP) inhibitors are approved for the treatment
of some men with advanced prostate cancer. Rare but serious side effects include …
of some men with advanced prostate cancer. Rare but serious side effects include …
[HTML][HTML] Hematopoietic stem cell fate under the influence of Ser/Thr protein phosphatases
M Alberich-Jorda, L Macurek - Haematologica, 2024 - pmc.ncbi.nlm.nih.gov
Hematopoietic stem cells (HSC) are multipotent cells capable of unlimited self-renewal and
are essential for production of blood and immune cells throughout life. HSC reside in a …
are essential for production of blood and immune cells throughout life. HSC reside in a …