In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Pancreatic ductal adenocarcinomas (PDAC) depend on autophagy for survival; however,
the metabolic substrates that autophagy provides to drive PDAC progression are unclear …

The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma
(PDA) cells to pharmacologic inhibition of RAS–MAPK signaling are largely unknown. Using …

Iron (II) species can participate in the Fenton and Fenton‐like reactions to generate the
hydroxyl radical that can oxidatively damage biomolecules and induce oxidative stress in …

Simple Summary Iron is an essential element in human cells. Cells use iron for many
processes, such as proliferation, survival, DNA synthesis and energy production. However …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor survival rates.
Here, we evaluated iron-doped hydroxyapatite (FeHA) as a potential nanomedicine-based …

Ferroptosis has emerged as a new type of programmed cell death that can be harnessed for
cancer therapy. The concept of ferroptosis was for the first time proposed in in the early …

Purpose Iron acquisition is key to maintaining cell survival and function. Cancer cells in
general are considered to have an insatiable iron need. Iron delivery via the …