Therapeutic potential of snake venom in cancer therapy: current perspectives
Many active secretions produced by animals have been employed in the development of
new drugs to treat diseases such as hypertension and cancer. Snake venom toxins …
new drugs to treat diseases such as hypertension and cancer. Snake venom toxins …
Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
severe morbidity. Where mortality is mainly caused by venom toxins that induce …
[HTML][HTML] Venom-based peptide therapy: Insights into anti-cancer mechanism
R Ma, R Mahadevappa, HF Kwok - Oncotarget, 2017 - ncbi.nlm.nih.gov
The 5-year relative survival rate of all types of cancer has increased significantly over the
past three decades partly due to the targeted therapy. However, still there are many targeted …
past three decades partly due to the targeted therapy. However, still there are many targeted …
Cytotoxicity of Snake Venoms and Cytotoxins From Two Southeast Asian Cobras (Naja sumatrana, Naja kaouthia): Exploration of Anticancer Potential, Selectivity …
Venoms of cobras (Naja spp.) contain high abundances of cytotoxins, which contribute to
tissue necrosis in cobra envenomation. The tissue-necrotizing activity of cobra cytotoxins …
tissue necrosis in cobra envenomation. The tissue-necrotizing activity of cobra cytotoxins …
Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice
The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja
nigricollis was investigated in a mouse model. Intradermal injection of venom induced a …
nigricollis was investigated in a mouse model. Intradermal injection of venom induced a …
Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …
Protective effect of N-acetylcysteine against oxidative stress induced by zearalenone via mitochondrial apoptosis pathway in SIEC02 cells
J Wang, M Li, W Zhang, A Gu, J Dong, J Li, A Shan - Toxins, 2018 - mdpi.com
Zearalenone (ZEN), a nonsteroidal estrogen mycotoxin, is widely found in feed and
foodstuffs. Intestinal cells may become the primary target of toxin attack after ingesting food …
foodstuffs. Intestinal cells may become the primary target of toxin attack after ingesting food …
[HTML][HTML] The myth of cobra venom cytotoxin: More than just direct cytolytic actions
Cobra venom cytotoxin (CTX) is a non-enzymatic three-finger toxin that constitutes 40–60%
of cobra venom. Thus, it plays an important role in the pathophysiology of cobra …
of cobra venom. Thus, it plays an important role in the pathophysiology of cobra …
Animal venoms have potential to treat cancer
B Chatterjee - Current topics in medicinal chemistry, 2018 - ingentaconnect.com
The resistance to chemotherapeutics by the cancerous cells has made its treatment more
complicated. Animal venoms have emerged as an alternative strategy for anti-cancer …
complicated. Animal venoms have emerged as an alternative strategy for anti-cancer …
Venom peptides in cancer therapy: An updated review on cellular and molecular aspects
Based on the high incidence and mortality rates of cancer, its therapy remains one of the
most vital challenges in the field of medicine. Consequently, enhancing the efficacy of …
most vital challenges in the field of medicine. Consequently, enhancing the efficacy of …