GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …

In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among
inputs, but how these factors interact during realistic patterns of activity is unknown. Here we …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited
understanding of the molecular and experience-dependent mechanisms that regulate …

Until recently, the study of plasticity of neural circuits focused almost exclusively on
potentiation and depression at excitatory synapses on principal cells. Other elements in the …

Rapid memory formation relies, at least in part, on long-term potentiation (LTP) of excitatory
synapses. Inhibitory interneurons of the hippocampus, which are essential for information …