Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How
this is accomplished is still poorly understood. Using purified yeast replication proteins and …

Abstract FACT (FAcilitates Chromatin Transcription) has long been considered to be a
transcription elongation factor whose ability to destabilize nucleosomes promotes RNAPII …

Gene expression programmes conferring cellular identity are achieved through the
organization of chromatin structures that either facilitate or impede transcription. Among the …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

Faithful transfer of parental histones to newly replicated daughter DNA strands is critical for
inheritance of epigenetic states. Although replication proteins that facilitate parental histone …

Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …

Maintenance of epigenetic integrity relies on coordinated recycling and partitioning of
parental histones and deposition of newly synthesized histones during DNA replication. This …