Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development
MF Nagoor Meeran, H Javed, H Al Taee… - Frontiers in …, 2017 - frontiersin.org
Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline
monoterpene phenol. It is one of the most important dietary constituents in thyme species …
monoterpene phenol. It is one of the most important dietary constituents in thyme species …
Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review
ZW Wong, PV Thanikachalam… - Biomedicine & …, 2017 - Elsevier
Modern medicine has been used to treat myocardial infarction, a subset of cardiovascular
diseases, and have been relatively effective but not without adverse effects. Consequently …
diseases, and have been relatively effective but not without adverse effects. Consequently …
α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome …
MFN Meeran, S Azimullah, F Laham, S Tariq… - Food & function, 2020 - pubs.rsc.org
Emerging evidence demonstrates that NLRP3 inflammasome activation, lysosomal
dysfunction, and impaired autophagic flux play a crucial role in the pathophysiology of …
dysfunction, and impaired autophagic flux play a crucial role in the pathophysiology of …
Nerolidol, a sesquiterpene from the essential oils of aromatic plants, attenuates doxorubicin-induced chronic cardiotoxicity in rats
MFN Meeran, S Azimullah, HH Mamoudh… - Journal of Agricultural …, 2021 - ACS Publications
The clinical usage of doxorubicin (DOX), a potent anthracycline antineoplastic drug, is
limited due to its cardiotoxicity. The aim of this study was to assess the possible …
limited due to its cardiotoxicity. The aim of this study was to assess the possible …
Thymol, a dietary monoterpene phenol abrogates mitochondrial dysfunction in β-adrenergic agonist induced myocardial infarcted rats by inhibiting oxidative stress
MFN Meeran, GS Jagadeesh, P Selvaraj - Chemico-Biological Interactions, 2016 - Elsevier
Mitochondrial dysfunction has been suggested to be one of the important pathological
events in isoproterenol (ISO), a synthetic catecholamine and β-adrenergic agonist induced …
events in isoproterenol (ISO), a synthetic catecholamine and β-adrenergic agonist induced …
Nootkatone, a dietary fragrant bioactive compound, attenuates dyslipidemia and intramyocardial lipid accumulation and favorably alters lipid metabolism in a rat …
MFN Meeran, S Azimullah, MM Al Ahbabi, NK Jha… - Molecules, 2020 - mdpi.com
In the present study, we assessed whether nootkatone (NKT), a sesquiterpene in edible
plants, can provide protection against dyslipidemia, intramyocardial lipid accumulation, and …
plants, can provide protection against dyslipidemia, intramyocardial lipid accumulation, and …
Protective effects of α‐bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol‐induced myocardial infarction: In vivo …
MFN Meeran, F Laham, H Al‐Taee… - … of biochemical and …, 2018 - Wiley Online Library
The effect of α‐bisabolol on hemodyanimcs, lipid peroxidation, and nonenzymatic
antioxidants was evaluated in isoproterenol‐induced myocardial infarction in rats. They …
antioxidants was evaluated in isoproterenol‐induced myocardial infarction in rats. They …
α-Bisabolol abrogates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and intrinsic pathway of apoptosis in rats
MF Nagoor Meeran, F Laham, S Azimullah… - Molecular and cellular …, 2019 - Springer
Mitochondrial dysfunction plays crucial role in the pathologenesis of myocardial infarction
(MI). The present study evaluated the protective effect of α-bisabolol against isoproterenol …
(MI). The present study evaluated the protective effect of α-bisabolol against isoproterenol …
Icariin attenuates isoproterenol-induced cardiac toxicity in Wistar rats via modulating cGMP level and NF-κB signaling cascade
Icariin, a major component of Epimedium species, was evaluated using isoproterenol (ISO)-
induced cardiotoxicity in Wistar rats. Rats were treated with icariin at the doses of 1, 5, and …
induced cardiotoxicity in Wistar rats. Rats were treated with icariin at the doses of 1, 5, and …
Prophylactic treatment with icariin prevents isoproterenol-induced myocardial oxidative stress via nuclear factor-like 2 activation
Introduction: Icariin, a major component of Epimedium species and a mild
phosphodiesterase 5 (PDE-5) inhibitor, was evaluated for the prevention of myocardial …
phosphodiesterase 5 (PDE-5) inhibitor, was evaluated for the prevention of myocardial …