Cardiovascular diseases (CVDs) are arguably the most important comorbidities in chronic
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …

Pulmonary atelectasis is common in the perioperative period. Physiologically, it is produced
when collapsing forces derived from positive pleural pressure and surface tension overcome …

Rationale: Endobronchial valves (EBVs) have been successfully used in patients with
severe heterogeneous emphysema to improve lung physiology. Limited available data …

Rationale: This is the first multicenter randomized controlled trial to evaluate the
effectiveness and safety of Zephyr Endobronchial Valve (EBV) in patients with little to no …

Background Endobronchial valves that allow air to escape from a pulmonary lobe but not
enter it can induce a reduction in lobar volume that may thereby improve lung function and …

Background Lung-volume–reduction surgery has been proposed as a palliative treatment
for severe emphysema. Effects on mortality, the magnitude and durability of benefits, and …

Background Lung-volume–reduction surgery is a proposed treatment for emphysema, but
optimal selection criteria have not been defined. The National Emphysema Treatment Trial …

This study examines the hypothesis that the cigarette smoke-induced inflammatory process
is amplified in severe emphysema and explores the association of this response with latent …

BACKGROUND: The National Emphysema Treatment Trial defined subgroups of patients
with severe emphysema in whom lung-volume-reduction surgery (LVRS) improved survival …

Background Few treatment options exist for patients with severe emphysema. We assessed
the clinical benefits and safety of lung volume reduction coils (LVRCs) for the treatment of …