Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression
B Van Steensel, AS Belmont - Cell, 2017 - cell.com
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
Lamina-associated domains: peripheral matters and internal affairs
At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …
associated domains (LADs) aid functional organization of the genome. We review the …
Condensin-driven remodelling of X chromosome topology during dosage compensation
The three-dimensional organization of a genome plays a critical role in regulating gene
expression, yet little is known about the machinery and mechanisms that determine higher …
expression, yet little is known about the machinery and mechanisms that determine higher …
[HTML][HTML] LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
I Solovei, AS Wang, K Thanisch, CS Schmidt, S Krebs… - Cell, 2013 - cell.com
Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
[HTML][HTML] Structural and functional diversity of topologically associating domains
Recent studies have shown that chromosomes in a range of organisms are
compartmentalized in different types of chromatin domains. In mammals, chromosomes form …
compartmentalized in different types of chromatin domains. In mammals, chromosomes form …
Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence
W Meuleman, D Peric-Hupkes, J Kind… - Genome …, 2013 - genome.cshlp.org
In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …
organization of interphase chromosomes, by providing anchoring sites for large genomic …
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery
The factors that sequester transcriptionally repressed heterochromatin at the nuclear
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …
Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability
P Zeller, J Padeken, R van Schendel, V Kalck… - Nature …, 2016 - nature.com
Abstract Histone H3 lysine 9 (H3K9) methylation is a conserved modification that generally
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …
represses transcription. In Caenorhabditis elegans it is enriched on silent tissue-specific …