During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

ABSTRACT Coal workers' pneumoconiosis (CWP), as part of the spectrum of coal mine dust
lung disease (CMDLD), is a preventable but incurable lung disease that can be complicated …

Constitutive p16 Ink4a expression, along with senescence-associated β-galactosidase
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …

Acute kidney injury (AKI) is a common clinical problem, and patients who survive AKI have a
high risk of chronic kidney disease (CKD). The mechanism of CKD post‐AKI, characterized …

Background The FDA-approved small-molecule drug dasatinib is currently used as a
treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on …

Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen
deposition occurs in the extracellular matrix. At first sight, it is expected that the level of …

The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is
related to uterine aging. Senolytic therapies are an option for reducing health complications …

Silicosis is the most common pneumoconiosis globally, with higher prevalence and
incidence in developing countries. To date, there is no effective treatment to halt or reverse …

Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …

Dasatinib (DAS) exhibits anti-inflammatory effects by retrieving the balance between
inflammatory and anti-inflammatory cytokines secreted by macrophages. The aim of this …