Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Intestinal ischemia-reperfusion (I/R) injury is a common pathological process with high
clinical morbidity and mortality. Paeoniflorin, a monoterpene glucoside, is found to have …

Lung cancer is the leading cause of cancer death worldwide. Cisplatin is the major DNA-
Damaging anticancer drug that cross-links the DNA in cancer cells, but many patients …

Metabolic reprogramming is a critical pathogenesis of colorectal cancer (CRC), referring to
metabolic disorders that cancer cells make in response to the stimulating pressure …

Cancer is still considered a “hopeless case”, which seriously endangers human health.
Therefore, it is of great significance to research and develop novel anticancer drugs. Active …

Significance: The nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated
protein 1 (NRF2/KEAP1) pathway is a crucial and highly conserved defensive system that is …

Background In the event of amino acid starvation, the cell activates two main protective
pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and …

In recent years, the role of cellular metabolism in immunity has come into the focus of many
studies. These processes form a basis for the maintenance of tissue integrity and …

Abstract Background Nicotinamide N-methyltransferase (NNMT) is highly expressed in
several cancers and can regulate cell epigenetic status and various cell metabolism …