As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Soft tissue losses from tumor removal, trauma, aging, and congenital malformation affect
millions of people each year. Existing options for soft tissue restoration have several …

Skin aging is a multifactorial process consisting of two distinct and independent
mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and …

Accumulation and turnover of extracellular matrix components are the hallmarks of tissue
injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety …

Wound healing is the physiologic response to tissue trauma proceeding as a complex
pathway of biochemical reactions and cellular events, secreted growth factors, and …

Wound healing involves a series of carefully modulated steps, from initial injury and blood
clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between …

Glycosaminoglycans are native components of the extracellular matrix that drive cell
behavior and control the microenvironment surrounding cells, making them promising …

Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

We developed an injectable gelatin/hyaluronic acid hydrogel with slow degradability, which
consisted of carbohydrazide-modified gelatin (Gel-CDH) and hyaluronic acid monoaldehyde …