Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
From promises to practical strategies in epigenetic epidemiology
J Mill, BT Heijmans - Nature Reviews Genetics, 2013 - nature.com
The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …
complex phenotypes across the biomedical sciences. The standard research approaches …
Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs
F Yuan, T Yuan, L Sui, Z Wang, Z Xi, Y Li, X Li… - Nature …, 2018 - nature.com
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …
applications on account of carbon's intrinsic merits of high stability, low cost, and …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …
longevity, yet the causes and functional consequences of these variants remain unclear. To …
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …
maintaining cellular phenotype during differentiation, but little is known about the normal …
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …
regulation and disease, but little is known about the mechanisms underlying inter-individual …
Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome
Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Abstract Analysis of DNA methylation patterns relies increasingly on sequencing-based
profiling methods. The four most frequently used sequencing-based technologies are the …
profiling methods. The four most frequently used sequencing-based technologies are the …
Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
Autism spectrum disorder (ASD) defines a group of common, complex neurodevelopmental
disorders. Although the aetiology of ASD has a strong genetic component, there is …
disorders. Although the aetiology of ASD has a strong genetic component, there is …