Peptides and proteins are widely used to treat a range of medical conditions; however, they
often have to be injected and their effects are short-lived. These shortcomings of the native …

The bioconjugation of proteins—that is, the creation of a covalent link between a protein and
any other molecule—has been studied for decades, partly because of the numerous …

Chemists, biologists, and material scientists alike have long sought to control protein
presentation, orientation, and activity within biomaterials to dictate reaction catalysis …

In the late 70's, the discovery of the restriction enzymes made possible the biological
production of functional proteins by recombinant DNA technologies, a fact that largely …

Site-selective acetylation of a single lysine residue in a protein that reaches a lysine
acetyltransferase's accuracy, precision, and reliability is challenging. Here, we report a …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …

Numerous strategies for linking desired chemical probes with target peptides and proteins
have been developed and applied in the field of biological chemistry. Approaches for site …

The demand for creation of protein diversity and regulation of protein function through native
protein modification and post-translational modification has ignited the development of …

Bacterial biofilms are composed of a consortium of bacteria that communicate with each
other through quorum sensing. Therefore, bacteria can form an extracellular matrix, which is …

Site‐specific introduction of multiple components into peptides is greatly needed for the
preparation of densely functionalized and structurally uniform peptides. In this regard, N …