Animal genomes are folded in topologically associating domains (TADs) that have been
linked to the regulation of the genes they contain by constraining regulatory interactions …

During early development, the hindbrain is sub-divided into rhombomeres that underlie the
organisation of neurons and adjacent craniofacial tissues. A gene regulatory network of …

The zebrafish (Danio rerio) has been widely used in the study of human disease and
development, and about 70% of the protein-coding genes are conserved between the two …

The planarian Schmidtea mediterranea is being studied as a model species for
regeneration, but the assembly of planarian genomes remains challenging. Here, we report …

Segmentation of the vertebrate hindbrain leads to the formation of rhombomeres, each with
a distinct anteroposterior identity. Specialised boundary cells form at segment borders that …

Cells perceive their microenvironment through chemical and physical cues. However, how
the mechanical signals are interpreted during embryonic tissue deformation to result in …

Elucidating the cellular and molecular mechanisms that regulate the balance between
progenitor cell proliferation and neuronal differentiation in the construction of the embryonic …

Tissue growth and morphogenesis are interrelated processes, whose tight coordination is
essential for the production of different cell fates and the timely precise allocation of stem cell …

The segregation of cells with distinct regional identity underlies formation of a sharp border,
which in some tissues serves to organise a boundary signaling centre. It is unclear whether …

The dorsal telencephalon (ie the pallium) exhibits high anatomical diversity across
vertebrate classes. The non-mammalian dorsal pallium accommodates various …