Cardiac tumors: diagnosis, prognosis, and treatment

R Bussani, M Castrichini, L Restivo, E Fabris… - Current cardiology …, 2020 - Springer
Abstract Purpose of Review Cardiac masses frequently present significant diagnostic and
therapeutic clinical challenges and encompass a broad set of lesions that can be either …

Pathology, imaging, and treatment of cardiac tumours

JJ Maleszewski, NS Anavekar, TJ Moynihan… - Nature Reviews …, 2017 - nature.com
Cardiac tumours are a rare, but often devastating, clinical diagnosis. They encompass a
broad set of lesions that include both neoplastic and non-neoplastic conditions. Cardiac …

Tuberous sclerosis: current update

MX Wang, N Segaran, S Bhalla, PJ Pickhardt… - Radiographics, 2021 - pubs.rsna.org
Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant neurocutaneous
disorder secondary to mutations in the TSC1 or TSC2 tumor suppressor genes. Although …

Safety and efficacy of mTOR inhibitor treatment in patients with tuberous sclerosis complex under 2 years of age–a multicenter retrospective study

A Saffari, I Brösse, A Wiemer-Kruel, B Wilken… - Orphanet journal of rare …, 2019 - Springer
Background Tuberous sclerosis complex (TSC) is a multisystem disease with prominent
neurologic manifestations such as epilepsy, cognitive impairment and autism spectrum …

Treatment of cardiac rhabdomyomas with mTOR inhibitors in children with tuberous sclerosis complex—a systematic review

M Sugalska, A Tomik, S Jóźwiak, B Werner - International Journal of …, 2021 - mdpi.com
Background: Cardiac rhabdomyomas (CRs) are the earliest sign of tuberous sclerosis
complex (TSC). Most of them spontaneously regress after birth. However, multiple and/or …

[HTML][HTML] Fetal primary cardiac tumors during perinatal period

SM Yuan - Pediatrics & Neonatology, 2017 - Elsevier
Fetal primary cardiac tumors are rare, but they may cause complications, which are
sometimes life threatening, including arrhythmias, hydrops fetalis, ventricular outflow/inflow …

Regression of neonatal cardiac rhabdomyoma in two months through low-dose everolimus therapy: a report of three cases

JS Chang, PY Chiou, SH Yao, IC Chou, CY Lin - Pediatric Cardiology, 2017 - Springer
Cardiac rhabdomyoma (CR) is the most common cardiac tumor in newborns. Approximately
75% of cases are associated with tuberous sclerosis complex. Although these tumors …

The role of mTOR inhibitors in preventing epileptogenesis in patients with TSC: current evidence and future perspectives

S Schubert-Bast, F Rosenow, KM Klein, PS Reif… - Epilepsy & Behavior, 2019 - Elsevier
Tuberous sclerosis complex (TSC) is one of the most common genetic causes of epilepsy.
Mutations in the TSC1 or TSC2 genes lead to the dysregulation of the mechanistic target of …

Everolimus for the treatment of tuberous sclerosis complex–related cardiac rhabdomyomas in pediatric patients

N Dahdah - The Journal of pediatrics, 2017 - jpeds.com
Cardiac rhabdomyoma (cRHM), a benign, smooth-muscle hamartoma, occurs
predominantly in infants and children; approximately 75% of affected children are aged≤ 1 …

Giant left ventricular rhabdomyoma treated successfully with everolimus: case report and review of literature

A Martínez-García, C Michel-Macías… - Cardiology in the …, 2018 - cambridge.org
IntroductionIntracardiac rhabdomyomas can cause severe ventricular dysfunction and
outflow tract obstruction. Case reportA term newborn infant with antenatal diagnosis of giant …