The neuropathological hallmarks of Alzheimer disease (AD) include “positive” lesions such
as amyloid plaques and cerebral amyloid angiopathy, neurofibrillary tangles, and glial …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …

The toxicity of amyloid‐forming proteins is correlated with their interactions with cell
membranes. Binding events between amyloidogenic proteins and membranes result in …

Aggregation of α-synuclein (α-syn) has been linked to the pathogenesis of Parkinson's
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …

Dementia with Lewy bodies (DLB) and Parkinson's Disease (PD) are common causes of
motor and cognitive deficits and are associated with the abnormal accumulation of alpha …

Accumulation of the synaptic protein α-synuclein (α-syn) is a hallmark of Parkinson's disease
(PD) and Lewy body disease (LBD), a heterogeneous group of disorders with dementia and …

Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder
characterized by a profound and selective loss of nigrostriatal dopaminergic neurons …