Phosphatidylcholine biosynthesis and lipoprotein metabolism

LK Cole, JE Vance, DE Vance - … et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Phosphatidylcholine (PC) is the major phospholipid component of all plasma lipoprotein
classes. PC is the only phospholipid which is currently known to be required for lipoprotein …

Mechanisms of glycerophospholipid homeostasis in mammalian cells

M Hermansson, K Hokynar, P Somerharju - Progress in lipid research, 2011 - Elsevier
The membranes of mammalian cells contain hundreds of different phospholipid species, a
variety of glycolipids and cholesterol. While the reasons for such compositional diversity are …

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

W Palm, JL Sampaio, M Brankatschk, M Carvalho… - PLoS …, 2012 - journals.plos.org
Interorgan lipid transport occurs via lipoproteins, and altered lipoprotein levels correlate with
metabolic disease. However, precisely how lipoproteins affect tissue lipid composition has …

Formation and regulation of mitochondrial membranes

LC Schenkel, M Bakovic - International journal of cell biology, 2014 - Wiley Online Library
Mitochondrial membrane phospholipids are essential for the mitochondrial architecture, the
activity of respiratory proteins, and the transport of proteins into the mitochondria. The …

Multiplexed and single cell tracing of lipid metabolism

C Thiele, K Wunderling, P Leyendecker - Nature Methods, 2019 - nature.com
Cellular lipid metabolism is a complex network process comprising dozens of enzymes,
multiple organelles and more than a thousand lipid species. Tracing metabolic reactions in …

[HTML][HTML] Phospholipid methylation in mammals: from biochemistry to physiological function

DE Vance - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the
conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation …

Physiological roles of phosphatidylethanolamine N-methyltransferase

DE Vance - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of
phosphatidylethanolamine to phosphatidylcholine (PC). This 22.3 kDa protein is localized to …

Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo [S]

CJ Pynn, NG Henderson, H Clark, G Koster… - Journal of lipid …, 2011 - ASBMB
Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-
choline) pathway in rat liver generates predominantly mono-and di-unsaturated molecular …

Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis

DE Vance - Current opinion in lipidology, 2008 - journals.lww.com
Role of phosphatidylcholine biosynthesis in the regulation o... : Current Opinion in Lipidology
Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis …

Integrative systemic and local metabolomics with impact on survival in high-grade serous ovarian cancer

A Bachmayr-Heyda, S Aust, K Auer, SM Meier… - Clinical Cancer …, 2017 - AACR
Purpose: Cancer metabolism is characterized by alterations including aerobic glycolysis,
oxidative phosphorylation, and need of fuels and building blocks. Experimental Design …