[HTML][HTML] Beyond controlling cell size: functional analyses of S6K in tumorigenesis
As a substrate and major effector of the mammalian target of rapamycin complex 1
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …
(mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been …
PDK1: At the crossroad of cancer signaling pathways
Rational target therapy of cancer would benefit from the identification of new targets that can
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …
be easily inhibited by small molecules. An increasing amount of evidence hints at 3 …
[HTML][HTML] Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
Master kinase PDK1 in tumorigenesis
N Zheng, J Wei, D Wu, Y Xu, J Guo - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome
H Hu, Y Qin, G Bochorishvili, Y Zhu… - Journal of …, 2008 - Soc Neuroscience
Fragile X syndrome, caused by the loss of FMR1 gene function and loss of fragile X mental
retardation protein (FMRP), is the most commonly inherited form of mental retardation. The …
retardation protein (FMRP), is the most commonly inherited form of mental retardation. The …
PDK1: the major transducer of PI 3-kinase actions
JR Bayascas - Phosphoinositide 3-kinase in Health and Disease …, 2011 - Springer
Most of the cellular responses to phosphatidylinositol 3-kinase activation and
phosphatidylinositol 3, 4, 5-trisphosphate production are mediated by the activation of a …
phosphatidylinositol 3, 4, 5-trisphosphate production are mediated by the activation of a …
DsbA-L alleviates endoplasmic reticulum stress–induced adiponectin downregulation
OBJECTIVE Obesity impairs adiponectin expression, assembly, and secretion, yet the
underlying mechanisms remain elusive. The aims of this study were 1) to determine the …
underlying mechanisms remain elusive. The aims of this study were 1) to determine the …
[HTML][HTML] Up-regulation of adiponectin by resveratrol: the essential roles of the Akt/FOXO1 and AMP-activated protein kinase signaling pathways and DsbA-L
The natural polyphenol resveratrol (RSV) displays a wide spectrum of health beneficial
activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV …
activities, yet the precise mechanisms remain to be fully elucidated. Here we show that RSV …
Regulation of 3-phosphoinositide–dependent protein kinase 1 activity by homodimerization in live cells
TA Masters, V Calleja, DA Armoogum, RJ Marsh… - Science …, 2010 - science.org
3-Phosphoinositide–dependent kinase 1 (PDK1) plays a central role in regulating the
activity of protein kinases that are essential for signaling; however, how PDK1 itself is …
activity of protein kinases that are essential for signaling; however, how PDK1 itself is …
[HTML][HTML] PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis
CB Pollock, Y Yin, H Yuan, X Zeng, S King, X Li… - PloS one, 2011 - journals.plos.org
Peroxisome proliferator-activated receptorδ (PPARδ) is a transcription factor that is
associated with metabolic gene regulation and inflammation. It has been implicated in tumor …
associated with metabolic gene regulation and inflammation. It has been implicated in tumor …