DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …
throughput technologies enable omics studies interrogating thousands to millions of makers …
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation
Smoking is a major risk factor in many diseases. Genome wide association studies have
linked genes for nicotine dependence and smoking behavior to increased risk of …
linked genes for nicotine dependence and smoking behavior to increased risk of …
The role of cigarette smoke-induced epigenetic alterations in inflammation
D Zong, X Liu, J Li, R Ouyang, P Chen - Epigenetics & Chromatin, 2019 - Springer
Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …
Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation
F Guida, TM Sandanger, R Castagné… - Human molecular …, 2015 - academic.oup.com
Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …
smoking. However, an aspect that did not receive much attention is the evolution of …
DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies
X Gao, M Jia, Y Zhang, LP Breitling, H Brenner - Clinical epigenetics, 2015 - Springer
Active smoking is a major preventable public health problem and an established critical
factor for epigenetic modification. In this systematic review, we identified 17 studies …
factor for epigenetic modification. In this systematic review, we identified 17 studies …
Accounting for population stratification in DNA methylation studies
ABSTRACT DNA methylation is an important epigenetic mechanism that has been linked to
complex diseases and is of great interest to researchers as a potential link between …
complex diseases and is of great interest to researchers as a potential link between …