Progress and prospects toward supramolecular bioactive ion transporters

A Mondal, M Ahmad, D Mondal… - Chemical …, 2023 - pubs.rsc.org
The majority of cellular physiological processes depend on natural ion channels, which are
pore-forming membrane-embedded proteins that let ions flow across the cell membranes …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

A Photoswitchable Macrocycle Controls Anion‐Templated Pseudorotaxane Formation and Axle Relocalization

J de Jong, MA Siegler, SJ Wezenberg - Angewandte Chemie, 2024 - Wiley Online Library
Important biological processes, such as signaling and transport, are regulated by dynamic
binding events. The development of artificial supramolecular systems in which binding …

Self‐Assembled Hydrazide‐Based Nanochannels: Efficient Water Translocation and Salt Rejection

A Mondal, D Mondal, S Sarkar, U Shivpuje… - Angewandte …, 2025 - Wiley Online Library
Nature has ingeniously developed specialized water transporters that effectively reject ions,
including protons, while transporting water across membranes. These natural water …

Photo‐activation of Tolane‐based Synthetic Ion Channel for Transmembrane Chloride Transport

S Chattopadhayay, KV Banzal… - Angewandte Chemie, 2025 - Wiley Online Library
While natural channels respond to external stimuli to regulate ion concentration across cell
membranes, creating a synthetic version remains challenging. Here, we present a photo …

Nontoxic Artificial Chloride Channel Formation in Epithelial Cells by Isophthalic Acid‐Based Small Molecules

A Mondal, GK Barik, S Sarkar, D Mondal… - … A European Journal, 2023 - Wiley Online Library
Artificial channels capable of facilitating the transport of Cl− ions across cell membranes
while being nontoxic to the cells are rare. Such synthetic ion channels can mimic the …

Apoptosis‐Inducing Activity of a 2‐Hydroxyphenyl Benzamide‐Based Self‐Assembled Anion Channel

A Mondal, GK Barik, S Sarkar, U Shivpuje… - … –A European Journal - Wiley Online Library
Despite the significant interest in designing artificial ion channels, there is limited availability
of channel‐forming molecules to tackle complex issues, especially in biological systems …