Obesity is increasingly prevalent worldwide, with genetic factors contributing to its
development. The hypothalamic leptin-melanocortin pathway is central to the regulation of …

Appetite, as the internal drive for food intake, is often dysregulated in a broad spectrum of
conditions associated with over-and under-nutrition across the lifespan. Appetite regulation …

Purpose Patients with tumors involving the hypothalamic region are at high risk of
developing morbid obesity due to disturbances in the appetite regulative nuclei in …

Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental
evidence that endorses the important contribution of brain circuits to this condition. The …

Abstract Purpose Craniopharyngiomas (CPs) often lead to growth hormone deficiency
(GHD) in children. Growth hormone replacement therapy (GHRT) is essential for managing …

Pituitary patients with acquired HO a mean weight loss of 6.3% after 6 months of treatment
with acceptable and manageable side effects (headache, dry mouth, and sleep …

Background Low-grade glioma is the most common brain tumor in children with different
modes of treatment and a high overall survival. Low-grade glioma is considered a chronic …

Seipin is a key regulator of lipid metabolism, the deficiency of which leads to severe
lipodystrophy. Hypothalamus is the pivotal center of brain that modulates appetite and …

Background The hypothalamus, a neuro-endocrine gland located centrally in the brain,
weighs only on average 4 grams but is the captain on the ship of our energy balance. In the …

Setmelanotide: new promise for the treatment of hypothalamic obesity? Setmelanotide: new
promise for the treatment of hypothalamic obesity? Lancet Diabetes Endocrinol. 2024 Jun;12(6):366-367 …