Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

NF‐κB is responsible for upregulating gene products that control cell survival. In this study,
we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone …

Resveratrol, a phytoalexin, has recently gained attention for protective effects against
metabolic and cardiac diseases. The beneficial effects of resveratrol have been linked to …

Axonal degeneration is an active program of self-destruction that is observed in many
physiological and pathological settings. In Wallerian degeneration slow (wlds) mice …

Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …

The discovery and interpretation of peroxisome proliferator-activated receptor γ coactivator
1α (PGC-1α) protein in mitochondrial biogenesis, skeletal muscle and adipose tissue …

Resveratrol, a small molecule found in red wine, is reported to slow aging in simple
eukaryotes and has been suggested as a potential calorie restriction mimetic. Resveratrol …

Bioactive small molecules are critical in Aspergillus species during their development and
interaction with other organisms. Genes dedicated to their production are encoded in …

Nonselective inhibitors of human histone deacetylases (HDAC) are known to have antitumor
activity in mice in vivo, and several of them are under clinical investigation. The first of these …