It is becoming clear that epigenetic changes are involved in human disease as well as
during normal development. A unifying theme of disease epigenetics is defects in …

Research conducted over the past two decades has shown the importance of the type 1
insulin-like growth factor receptor (IGF1R) in tumorigenesis, metastasis, and resistance to …

The application of primary organoid cultures containing epithelial and mesenchymal
elements to cancer modeling holds promise for combining the accurate multilineage …

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

IGF-1R inhibitors arrived in the clinic accompanied by optimism based on preclinical activity
of IGF-1R targeting, and recognition that low IGF bioactivity protects from cancer. This was …

The insulin-like growth factor (IGF) 2/IGF1 receptor (IGF1R) signaling axis has an important
role in intestinal carcinogenesis and overexpression of IGF2 is an accepted risk factor for …

Colorectal cancer (CRC) is one of the most common cancers in men and women worldwide
as well as is the leading cause of death in the western world. Almost a third of the patients …

Tissue-specific stem cells have unique properties and growth requirements, but a small set
of juxtacrine and paracrine signals have been identified that are required across multiple …

A number of studies performed on rodents suggest that insulin-like growth factor 2 (IGF-2) or
its analogs may possibly be used for treating some conditions like Alzheimer's disease …

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …