Single-cell multi-omics has recently emerged as a powerful technology by which different
layers of genomic output—and hence cell identity and function—can be recorded …

Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

The epigenomes of mammalian sperm and oocytes, characterized by gamete-specific 5-
methylcytosine (5mC) patterns, are reprogrammed during early embryogenesis to establish …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Geneticists study the gene; however, for epigeneticists, there is no obvious' epigene'.
Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings …

Pro-inflammatory autoantigen-specific CD4+ T helper (auto-Th) cells are central
orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

DNA methylation and histone modification exert epigenetic control over gene expression.
CHG methylation by CHROMOMETHYLASE3 (CMT3) depends on histone H3K9 …

DNA methylation patterns are set up early in mammalian development and are then copied
during the division of somatic cells. A long-established model for the maintenance of these …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …