Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Accumulating evidence suggests that disrupted brain insulin signaling promotes the
development and progression of Alzheimer's disease (AD), driving clinicians to target this …

Aim Insulin has a well-established role in cognition, neuronal detoxification and synaptic
plasticity. Insulin transduction affect neurotransmitter functions, influence bioenergetics and …

It is well known in clinical practice that Alzheimer's disease (AD) is closely associated with
brain insulin resistance, and the cerebral insulin pathway has been proven to play a critical …

Background: Axonopathy is closely linked to the development of diabetic encephalopathy
induced by type II diabetes (T2D). Berberine has been shown to cross the blood-brain …

Background Recently, we and other researchers reported that brain metabolic disorders are
implicated in Alzheimer's disease (AD), a progressive, devastating and incurable …

Diabetes mellitus continues to be a disease that affects a good percentage of our
population. The majority affected need insulin on a day-to-day basis. Before the invention of …

Maternal diabetes constitutes an unfavorable intrauterine environment for offspring
development. Although it is known that diabetes can cause brain alterations and increased …

Significance: It is of common sense that the world population is aging and life expectancy is
increasing. However, as the population ages, there is also an exponential risk to live into the …

Diabetes mellitus is a chronic metabolic disease with a high prevalence in the Western
population. It is characterized by pancreas failure to produce insulin, which involves high …