Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …

Efficient and accurate DNA synthesis is enabled by DNA polymerase fidelity checkpoints
that promote insertion of the right instead of wrong nucleotide. Erroneous X-family …

Apart from surgical approaches, the treatment of cancer remains largely underpinned by
radiotherapy and pharmacological agents that cause damage to cellular DNA, which …

According to the RNA world hypothesis, self-replicating ribozymes, storing the genetic
information and being able to perform catalysis, were the constituents of the first living …

Objective To compare CYP1B1 and MYOC variants in a cohort of neonatal-onset (NO) and
infantile-onset (IO) primary congenital glaucoma (PCG). Methods This prospective …

Nucleoside reverse transcriptase inhibitors (NRTIs) are an important class of antiviral drugs
used to manage infections by human immunodeficiency virus, which causes AIDS …

Although lamivudine and emtricitabine, two L-deoxycytidine analogs, have been widely
used as antiviral drugs for years, a structural basis for D-stereoselectivity against L-dNTPs …

Oxo-7, 8,-dihydro-2′-deoxyguanosine triphosphate (8-oxo-dGTP) is a major product of
oxidative damage in the nucleotide pool. It is capable of mispairing with adenosine (dA) …

Antiviral nucleoside analogues have been developed to inhibit the enzymatic activities of the
hepatitis B virus (HBV) polymerase, thereby preventing the replication and production of …

DNA double-strand breaks (DSBs) resulting from reactive oxygen species generated by
exposure to UV and ionizing radiation are characterized by clusters of lesions near break …