Cancer stem cells (CSCs) are a sub-population of cells within cancer tissues with tumor
initiation, drug resistance and metastasis properties. CSCs also have been considered as …

Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness
is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could …

Neuroblastoma is a childhood tumour with heterogeneous characteristics and children with
metastatic disease often have a poor outcome. Here we describe the establishment of …

Head and neck squamous cell carcinoma (HNSCC) has a poor 5-year survival rate of 50%.
One potential reason for treatment failure is the presence of cancer stem cells (CSCs) …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a
receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report …

Background Neuroblastoma is a paediatric tumour originated from sympathoadrenal
precursors and characterized by its heterogeneity and poor outcome in advanced stages …

Background The successful targeting of neuroblastoma (NB) by associating tumor-initiating
cells (TICs) is a major challenge in the development of new therapeutic strategies. The …

Recently protocols have been devised for the culturing of cell lines from fresh tumours under
serum-free conditions in defined neural stem cell medium. These cells, frequently called …

Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-
risk neuroblastoma patients have a poor overall survival and account for~ 15% of childhood …