Different mechanisms contribute to intratumor heterogeneity, including genetic mutations,
the microenvironment, and the existence of subpopulations of cancer cells with increased …

Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of …

Background Acute myeloid leukemia (AML) remains a devastating disease with a 5-year
survival rate of less than 30%. AML treatment has undergone significant changes in recent …

Acute myeloid leukemia (AML) patients display dismal prognosis due to high prevalence of
refractory and relapsed disease resulting from chemoresistance. Treatment protocols …

We sought to identify drugs that could counteract cytarabine resistance in acute myeloid
leukemia (AML) by generating eight resistant variants from MOLM-13 and SHI-1 AML cell …

PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-
ALL), and children with inherited preleukemic PAX5 mutations are at a higher risk of …

A lack of practical resources in Japan has limited preclinical discovery and testing of
therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which …

Highlights•DNA replication timing profiling methodology for cryopreserved acute lymphoid
leukemia samples and patient-derived xenografts has been established.•Replication timing …

Cancer is characterized by a remarkable intertumoral, intratumoral, and cellular
heterogeneity that might be explained by the cancer stem cell (CSC) and/or the clonal …

Nucleoside and nucleotide analogs are essential tools in our limited arsenal in the fight
against cancer. However, these structures face severe drawbacks such as rapid plasma …