[HTML][HTML] Next-generation sequencing for confronting virus pandemics
Virus pandemics have happened, are happening and will happen again. In recent decades,
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of …
[HTML][HTML] Mixed HCV infection and reinfection in people who inject drugs—impact on therapy
EB Cunningham, TL Applegate, AR Lloyd… - Nature reviews …, 2015 - nature.com
The majority of new and existing cases of HCV infection in high-income countries occur
among people who inject drugs (PWID). Ongoing high-risk behaviours can lead to HCV re …
among people who inject drugs (PWID). Ongoing high-risk behaviours can lead to HCV re …
[HTML][HTML] SARS-CoV-2 mutant spectra at different depth levels reveal an overwhelming abundance of low frequency mutations
B Martínez-González, ME Soria, L Vázquez-Sirvent… - Pathogens, 2022 - mdpi.com
Populations of RNA viruses are composed of complex and dynamic mixtures of variant
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …
genomes that are termed mutant spectra or mutant clouds. This applies also to SARS-CoV …
Strategies for the improvement of HCV testing and diagnosis
S Chevaliez - Expert review of anti-infective therapy, 2019 - Taylor & Francis
Introduction: The improvement of number of people diagnosed with hepatitis C virus (HCV)
infection is crucial to reach the WHO objectives for eliminating viral hepatitis by 2030 …
infection is crucial to reach the WHO objectives for eliminating viral hepatitis by 2030 …
Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure
A percentage of hepatitis C virus (HCV)-infected patients fail direct acting antiviral (DAA)-
based treatment regimens, often because of drug resistance-associated substitutions (RAS) …
based treatment regimens, often because of drug resistance-associated substitutions (RAS) …
[HTML][HTML] Injecting drug use: A vector for the introduction of new hepatitis C virus genotypes
S Ruta, C Cernescu - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) genotypes' monitoring allows real-time insight into the dynamic
changes that occur in the global epidemiological picture of HCV infection. Intravenous drug …
changes that occur in the global epidemiological picture of HCV infection. Intravenous drug …
Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant
Background: Controversy is ongoing about whether a minority mutant present at frequencies
below 15% may be clinically relevant and should be considered to guide treatment …
below 15% may be clinically relevant and should be considered to guide treatment …
[HTML][HTML] Resistance of hepatitis C virus to inhibitors: complexity and clinical implications
Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-
species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent …
species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent …
[HTML][HTML] Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus
ME Soria, J Gregori, Q Chen, D García-Cehic… - BMC Infectious …, 2018 - Springer
Background Despite the high sustained virological response rates achieved with current
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …
directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5–10% of …
[HTML][HTML] Adaptive immune responses, immune escape and immune-mediated pathogenesis during HDV infection
V Oberhardt, M Hofmann, R Thimme… - Viruses, 2022 - mdpi.com
The hepatitis delta virus (HDV) is the smallest known human virus, yet it causes great harm
to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires …
to patients co-infected with hepatitis B virus (HBV). As a satellite virus of HBV, HDV requires …