The Chemical Reactivity of Membrane Lipids

G Duché, JM Sanderson - Chemical Reviews, 2024 - ACS Publications
It is well-known that aqueous dispersions of phospholipids spontaneously assemble into
bilayer structures. These structures have numerous applications across chemistry and …

Effects of nitro-oxidative stress on biomolecules: part 1—non-reactive molecular dynamics simulations

M Ghasemitarei, T Ghorbi, M Yusupov, Y Zhang… - Biomolecules, 2023 - mdpi.com
Plasma medicine, or the biomedical application of cold atmospheric plasma (CAP), is an
expanding field within plasma research. CAP has demonstrated remarkable versatility in …

[HTML][HTML] Mixed DPPC/POPC monolayers: all-atom molecular dynamics simulations and Langmuir monolayer experiments

A Olżyńska, M Zubek, M Roeselova… - … et Biophysica Acta (BBA …, 2016 - Elsevier
To elucidate the consequences of the saturated-unsaturated nature of lipid surface films,
monolayers formed by an equimolar mixture of 1-palmitoyl-2-oleyl-sn-glycero-3 …

[HTML][HTML] An overview of molecular dynamics simulations of oxidized lipid systems, with a comparison of ELBA and MARTINI force fields for coarse grained lipid …

P Siani, RM de Souza, LG Dias, R Itri… - Biochimica et Biophysica …, 2016 - Elsevier
Biological membranes and model lipid systems containing high amounts of unsaturated
lipids and sterols are subject to chemical and/or photo-induced lipid oxidation, which leads …

Degradation and rearrangement of a lung surfactant lipid at the air–water interface during exposure to the pollutant gas ozone

KC Thompson, SH Jones, AR Rennie, MD King… - Langmuir, 2013 - ACS Publications
The presence of unsaturated lipids in lung surfactant is important for proper respiratory
function. In this work, we have used neutron reflection and surface pressure measurements …

Structure and stability studies of mixed monolayers of saturated and unsaturated phospholipids under low-level ozone

L Qiao, A Ge, M Osawa, S Ye - Physical Chemistry Chemical Physics, 2013 - pubs.rsc.org
In the present study, stability and structure of single and binary mixed monolayers of an
unsaturated phospholipid, DOPC, and a saturated phospholipid, DPPC-d75, on the water …

The effects of the structure and composition of the hydrophobic parts of phosphatidylcholine-containing systems on phosphatidylcholine oxidation by ozone

E Rudolphi-Skórska, M Filek, M Zembala - The Journal of Membrane …, 2017 - Springer
The degree of lipid unsaturation is a parameter used to describe membrane susceptibility to
oxidation. This paper highlights the importance of double bond distribution in the …

[HTML][HTML] The lung surfactant activity probed with molecular dynamics simulations

A Stachowicz-Kuśnierz, B Korchowiec… - Advances in Colloid and …, 2022 - Elsevier
The surface of pulmonary alveolar subphase is covered with a mixture of lipids and proteins.
This lung surfactant plays a crucial role in lung functioning. It shows a complex phase …

Prednisolone adsorption on lung surfactant models: insights on the formation of nanoaggregates, monolayer collapse and prednisolone spreading

ED Estrada-López, E Murce, MPP Franca… - RSC advances, 2017 - pubs.rsc.org
The adsorption of prednisolone on a lung surfactant model was successfully performed
using coarse grained molecular dynamics. The prednisolone coarse grained model was …

Environmental pollutant ozone causes damage to lung surfactant protein B (SP-B)

JM Hemming, BR Hughes, AR Rennie, S Tomas… - Biochemistry, 2015 - ACS Publications
Lung surfactant protein B (SP-B) is an essential protein found in the surfactant fluid at the air–
water interface of the lung. Exposure to the air pollutant ozone could potentially damage SP …