The discovery of antibiotics has led to the effective treatment of bacterial infections that were
otherwise fatal and has had a transformative effect on modern medicine. Teixobactin is an …

Discovering new antibiotics with novel chemical scaffolds and antibacterial mechanisms
presents a challenge for medicinal scientists worldwide as the ever‐increasing bacterial …

Antimicrobial resistance is a serious threat to human health worldwide, prompting research
efforts on a massive scale in search of novel antibiotics to fill an urgent need for a remedy …

Antibiotics have served humankind through their use in modern medicine as effective
treatments for otherwise fatal bacterial infections. Teixobactin is a first member of newly …

This untargeted metabolomics study investigated the synergistic antibacterial activity of
polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis …

Staphylococcus aureus (S. aureus) is a significant Gram-positive opportunistic pathogen
behind many debilitating infections. β-lactam antibiotics are conventionally prescribed for …

Here we designed and synthesized analogs of two antimicrobial peptides, namely C10: 0-
A2, a lipopeptide, and TA4, a cationic α-helical amphipathic peptide, and used non …

Two thioamino acids and four fluorinated amino acids were employed to substitute either
partially or entirely the Ile 2, Ser 3, Ile 6, and Ser 7 residues of Leu 10-teixobactin to prepare …

The treatment of infections caused by biofilm-forming organisms is challenging. The newly
discovered antibiotic teixobactin shows activity against a wide range of biofilm-forming …

Backbone N-methylation as a posttranslational modification was recently discovered in a
class of ribosomally encoded peptides referred to as borosins. The founding members of the …