[HTML][HTML] Choices of morbidity outcomes and concentration–response functions for health risk assessment of long-term exposure to air pollution

F Forastiere, JV Spadaro, C Ancona… - Environmental …, 2024 - journals.lww.com
Background: Air pollution health risk assessment (HRA) has been typically conducted for all
causes and cause-specific mortality based on concentration–response functions (CRFs) …

Metabolic perturbations associated with an exposure mixture of per-and polyfluoroalkyl substances in the atlanta african american maternal-child cohort

D Liang, KR Taibl, AL Dunlop, DB Barr… - Environmental …, 2023 - ACS Publications
Prenatal exposure to single chemicals belonging to the per-and polyfluoroalkyl substances
(PFAS) family is associated with biological perturbations in the mother, fetus, and placenta …

The last decade of air pollution epidemiology and the challenges of quantitative risk assessment

F Forastiere, H Orru, M Krzyzanowski, JV Spadaro - Environmental Health, 2024 - Springer
Epidemiologic research and quantitative risk assessment play a crucial role in transferring
fundamental scientific knowledge to policymakers so they can take action to reduce the …

Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence

DR Healy, I Zarei, S Mikkonen, S Soininen… - Communications …, 2024 - nature.com
Environmental and lifestyle factors, including air pollution, impaired diet, and low physical
activity, have been associated with cardiometabolic risk factors in childhood and …

Lung cancer metabolomics: a pooled analysis in the Cancer Prevention Studies

Z Tang, D Liang, EL Deubler, JA Sarnat, SS Chow… - BMC medicine, 2024 - Springer
Background A better understanding of lung cancer etiology and the development of
screening biomarkers have important implications for lung cancer prevention. Methods We …

Mechanisms of toxicity: metabolomics promises new clarity on air pollution

F Pascual - Environmental Health Perspectives, 2023 - ehp.niehs.nih.gov
Air pollution contributes to an estimated 6.5 million deaths each year globally, 1 and even
though its adverse health effects are well documented, 2 establishing precise causal …

Invited perspective: application of nontargeted analysis in characterizing the maternal and child Exposome

D Liang, DI Walker - Environmental Health Perspectives, 2023 - ehp.niehs.nih.gov
1. Trowbridge J, Abrahamsson D, Bland GD, Jiang T, Wang M, Park JS, et al. 2023.
Extending nontargeted discovery of environmental chemical exposures during pregnancy …

Prenatal and Early Life Exposure to Ambient Air Pollutants Is Associated with the Fecal Metabolome in the First Two Years of Life

EA Holzhausen, BN Chalifour, Y Tan… - Environmental …, 2024 - ACS Publications
Prenatal and early life air pollution exposure has been linked with several adverse health
outcomes. However, the mechanisms underlying these relationships are not yet fully …

Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways

SL Cheng, M Hedges, P Keski-Rahkonen… - Environmental …, 2024 - ACS Publications
This randomized crossover study investigated the metabolic and mRNA alterations
associated with exposure to high and low traffic-related air pollution (TRAP) in 50 …

Metabolomics Signatures of Exposure to Ambient Air Pollution: A Large-Scale Metabolome-Wide Association Study in the Cancer Prevention Study-II Nutrition Cohort

D Liang, Z Tang, WR Diver, JA Sarnat… - Environmental …, 2024 - ACS Publications
Existing air pollution metabolomics studies showed inconsistent results, often limited by
small sample size and individual air pollutants effects. We conducted a metabolome-wide …