Is “delayed onset muscle soreness” a false friend? The potential implication of the fascial connective tissue in post-exercise discomfort

J Wilke, M Behringer - International journal of molecular sciences, 2021 - mdpi.com
Strenuous and unaccustomed exercise frequently lead to what has been coined “delayed
onset muscle soreness”(DOMS). As implied by this term, it has been proposed that the …

[HTML][HTML] Influence of routine exercise on the peripheral immune system to prevent and alleviate pain

JB Lesnak, G Berardi, KA Sluka - Neurobiology of Pain, 2023 - Elsevier
Routine physical activity reduces the onset of pain and exercise is a first line treatment for
individuals who develop chronic pain. In both preclinical and clinical research regular …

Functional impact of post-exercise cooling and heating on recovery and training adaptations: Application to resistance, endurance, and sprint exercise

T Chaillou, V Treigyte, S Mosely, M Brazaitis… - Sports medicine …, 2022 - Springer
The application of post-exercise cooling (eg, cold water immersion) and post-exercise
heating has become a popular intervention which is assumed to increase functional …

Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury

G James, KA Sluka, L Blomster, L Hall… - European Spine …, 2018 - Springer
Purpose Intervertebral disk (IVD) lesion and its subsequent degeneration have a profound
effect on the multifidus muscle. The subacute/early chronic phase of multifidus remodeling …

Dynamics of pleasure–displeasure at the limit of exercise tolerance: conceptualizing the sense of exertional physical fatigue as an affective response

ME Hartman, P Ekkekakis, ND Dicks… - Journal of …, 2019 - journals.biologists.com
The search for variables involved in the regulation and termination of exercise performance
has led to integrative models that attribute a central role to the brain and utilize an array of …

Peripheral mechanisms of ischemic myalgia

LF Queme, JL Ross, MP Jankowski - Frontiers in cellular …, 2017 - frontiersin.org
Musculoskeletal pain due to ischemia is present in a variety of clinical conditions including
peripheral vascular disease (PVD), sickle cell disease (SCD), complex regional pain …

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain

LA Pattison, RH Rickman, H Hilton, M Dannawi… - Proceedings of the …, 2024 - pnas.org
Inflammation is associated with localized acidosis, however, attributing physiological and
pathological roles to proton-sensitive receptors is challenging due to their diversity and …

P2X4 receptors on muscle macrophages are required for development of hyperalgesia in an animal model of activity-induced muscle pain

MC Oliveira-Fusaro, NS Gregory, SJ Kolker… - Molecular …, 2020 - Springer
Activity-induced pain is common in those with chronic musculoskeletal pain and limits
participation in daily activities and exercise. Our laboratory developed a model of activity …

Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury

JL Ross, LF Queme, JE Lamb, KJ Green… - Biology of sex …, 2018 - Springer
Background Chronic pain conditions are more prevalent in women, but most preclinical
studies into mechanisms of pain generation are performed using male animals …

Involvement of the Transient Receptor Channels in Preclinical Models of Musculoskeletal Pain

SQ Kudsi, FT Viero, LG Pereira… - Current …, 2024 - benthamdirect.com
Background: Musculoskeletal pain is a condition that affects bones, muscles, and tendons
and is present in various diseases and/or clinical conditions. This type of pain represents a …