Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in
patients with breast cancer, but some patients may be more susceptible to ionizing radiation …

Cancer is intimately related to the accumulation of DNA damage, and repair failures
(including mutation prone repair and hyperactive repair systems). This article relates current …

Ovarian cancer is the fifth most common female cancer in the Western world, and the
deadliest gynecological malignancy. The overall poor prognosis for ovarian cancer patients …

The class III histone deacetylase (HDAC) SIRT1 plays a role in the metabolism, aging, and
carcinogenesis of organisms and regulates senescence and apoptosis in cells. Recent …

Simple Summary Circulating tumor cells dissociate from the primary tumor, enter the
bloodstream and travel to distant sites where they seed metastases. To endow these tumor …

Quality control of DNA double-strand break (DSB) repair is vital in preventing mutagenesis.
Non-homologous end-joining (NHEJ), a repair process predominant in the G 1 phase of the …

DNA repair is a key determinant in the cellular response to therapy and tumor repair status
could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA …

It has been well-established that mutations in BRCA1 and BRCA2, compromising functions
in DNA double-strand break repair (DSBR), confer hereditary breast and ovarian cancer risk …

Ataxia telangiectasia mutated (ATM) has multiple functions in homologous recombination
(HR) and nonhomologous end joining (NHEJ), which lead to conflicting data regarding its …

Most presently known breast cancer susceptibility genes have been linked to DSB repair. To
identify novel markers that may serve as indicators for breast cancer risk, we performed DSB …