The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

Hypertension is a leading risk factor for stroke, heart disease and chronic kidney disease.
Multiple interacting factors and organ systems increase blood pressure and cause target …

Abstract The (pro) renin receptor ((P) RR) was first identified as a single-transmembrane
receptor in human kidneys and initially attracted attention owing to its potential role as a …

Reactive oxygen species derived from NADPH oxidase contribute to a wide variety of renal
diseases. Nox4, the major NADPH isoform in kidney, produces mainly H 2 O 2 that regulates …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

The extracellular domain of the (pro) renin receptor (PRR) is cleaved to produce a soluble
(pro) renin receptor (sPRR) that is detected in biological fluid and elevated under certain …

Reactive oxygen species (ROS) are ubiquitous metabolic products and important cellular
signaling molecules that contribute to several biological functions. Pathophysiology arises …

Reactive oxygen species (ROS) have been mainly viewed as unwanted by-products of
cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential …

Dysfunctional reactive oxygen species (ROS) signaling is considered an important disease
mechanism. Therapeutically, non-selective scavenging of ROS by antioxidants, however …