Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …
Following more than a century of study, many components and pathways contributing to …
Three-dimensional structure of kinetochore-fibers in human mitotic spindles
During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …
The SNHG1-centered ceRNA network regulates cell cycle and is a potential prognostic biomarker for hepatocellular carcinoma
L Zhou, Q Zhang, H Deng, S Ou, T Liang… - The Tohoku Journal of …, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) is one of the most common and lethal types of cancer. This
study aimed to identify the expression regulatory network and a prognostic signature of …
study aimed to identify the expression regulatory network and a prognostic signature of …
Activity Unmasks Chirality in Liquid-Crystalline Matter
A Maitra - Annual Review of Condensed Matter Physics, 2024 - annualreviews.org
Active matter theories naturally describe the mechanics of living systems. As biological
matter is overwhelmingly chiral, an understanding of the implications of chirality for the …
matter is overwhelmingly chiral, an understanding of the implications of chirality for the …
Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other
During mitosis, motor proteins and microtubule-associated protein organize the spindle
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …
Opposing motors provide mechanical and functional robustness in the human spindle
At each cell division, the spindle self-organizes from microtubules and motors. In human
spindles, the motors dynein and Eg5 generate contractile and extensile stress, respectively …
spindles, the motors dynein and Eg5 generate contractile and extensile stress, respectively …
Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling
C Edelmaier, AR Lamson, ZR Gergely, S Ansari… - Elife, 2020 - elifesciences.org
The essential functions required for mitotic spindle assembly and chromosome biorientation
and segregation are not fully understood, despite extensive study. To illuminate the …
and segregation are not fully understood, despite extensive study. To illuminate the …
Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
Within the mitotic spindle, kinesin motors cross-link and slide overlapping microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …
Torques within and outside the human spindle balance twist at anaphase
At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale
spindle. Many mitotic motors step helically around microtubules in vitro, and most are …
spindle. Many mitotic motors step helically around microtubules in vitro, and most are …