In the past, conventional drug discovery strategies have been successfully employed to
develop new drugs, but the process from lead identification to clinical trials takes more than …

Neglected tropical diseases continue to create high levels of morbidity and mortality in a
sizeable fraction of the world's population, despite ongoing research into new treatments …

Drug design and discovery is a process that requires high financial costs and is
timeconsuming. For many years, this process focused on empirical pharmacology. However …

Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

The neglected tropical disease (NTD) leishmaniasis is the collective name given to a diverse
group of illnesses caused by~ 20 species belonging to the genus Leishmania, a majority of …

The recent pandemic of severe acute respiratory syndrome–coronavirus2 (SARS-CoV-2)
infection (COVID-19) has put the world on serious alert. The main protease of SARS-CoV-2 …

COVID-19, which is caused by a novel coronavirus known as SARS-CoV-2, has spread
rapidly around the world, and it has infected more than 29 million individuals as recorded on …

COVID-19 has caused lockdowns all over the world in early 2020, as a global pandemic.
Both theoretical and experimental efforts are seeking to find an effective treatment to …

Parasitic diseases have serious health, social, and economic impacts, especially in the
tropical regions of the world. Diseases caused by protozoan parasites are responsible for …

In this report, we present the design and synthesis of a novel series of pyrimidine-tethered
spirochromane-based sulfonamide derivatives aimed at combating drug resistance in …