Chagas disease (CD) remains endemic throughout many regions of Colombia despite
implementing decades of vector control strategies in several departments. Some regions …

Extracellular vesicle (EVs) traffic is considered an important cellular communication process
between cells that can be part of a single organism or belong to different living beings. The …

Chagas disease, a neglected tropical disease (NTD) caused by the flagellated protozoan
Trypanosoma cruzi (T. cruzi), is a major public health problem. It was initially restricted to …

The interaction of the anti-beta1-adrenergic receptor autoantibodies (β1ARAb) and the anti-
muscarinic M2 receptor autoantibodies (M2RAb) with cardiac neurotransmitter receptors …

IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of the
immune response in many pathological conditions, including infectious diseases. Infection …

There is a growing consensus that the balance between the persistence of infection and the
host immune response is crucial for chronification of Chagas heart disease. Extrapolation for …

Phenothiazines inhibit antioxidant enzymes in trypanosomatids. However, potential
interferences with host cell antioxidant defenses are central concerns in using these drugs to …

Digestive Chagas disease (DCD) is an enteric neuropathy caused by Trypanosoma cruzi
infection. There is a lack of evidence on the mechanism of pathogenesis and rationales for …

Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the
Western Hemisphere, with an increasing number of cases, especially in non-endemic …

Chagas disease (CD), a disease affecting millions globally, remains shrouded in scientific
uncertainty, particularly regarding the role of the intestinal microbiota in disease …