Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges

W Zhang, A Mehta, Z Tong, L Esser… - Advanced …, 2021 - Wiley Online Library
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

The crown and the scepter: roles of the protein corona in nanomedicine

R Cai, C Chen - Advanced Materials, 2019 - Wiley Online Library
Engineering nanomaterials are increasingly considered promising and powerful biomedical
tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials …

Nanoparticles and innate immunity: new perspectives on host defence

D Boraschi, P Italiani, R Palomba, P Decuzzi… - Seminars in …, 2017 - Elsevier
The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …

Exposure to inorganic nanoparticles: routes of entry, immune response, biodistribution and in vitro/in vivo toxicity evaluation

V De Matteis - Toxics, 2017 - mdpi.com
The development of different kinds of nanoparticles, showing different physico-chemical
properties, has fostered their large use in many fields, including medicine. As a …

Nanoparticle–cell interactions: molecular structure of the protein corona and cellular outcomes

CC Fleischer, CK Payne - Accounts of chemical research, 2014 - ACS Publications
Conspectus The use of nanoparticles (NPs) in biology and medicine requires a molecular-
level understanding of how NPs interact with cells in a physiological environment. A critical …

Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect

V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …

Catalytic properties and biomedical applications of cerium oxide nanoparticles

C Walkey, S Das, S Seal, J Erlichman… - Environmental …, 2015 - pubs.rsc.org
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the
test tube, cell culture models and animal models of disease. However given the reactivity …

Nanoparticles and nanomaterials as plant biostimulants

A Juárez-Maldonado, H Ortega-Ortíz… - International Journal of …, 2019 - mdpi.com
Biostimulants are materials that when applied in small amounts are capable of promoting
plant growth. Nanoparticles (NPs) and nanomaterials (NMs) can be considered as …

Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood

MI Setyawati, CY Tay, D Docter, RH Stauber… - Chemical Society …, 2015 - pubs.rsc.org
While the blood vessel is seldom the target tissue, almost all nanomedicine will interact with
blood vessels and blood at some point of time along its life cycle in the human body …

Controlling the stealth effect of nanocarriers through understanding the protein corona

S Schöttler, K Landfester… - Angewandte Chemie …, 2016 - Wiley Online Library
The past decade has seen a significant increase in interest in the use of polymeric
nanocarriers in medical applications. In particular, when used as drug vectors in targeted …